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Updated: May 25, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

The metabolic effects of two different lipid emulsions used in parenterally fed premature infants--a randomized

Gamze Demirel1, Serife Suna Oguz, Istemi Han Celik

  • 1Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. kgamze@hotmail.com

Early Human Development
|January 17, 2012
PubMed

Insights

Soybean oil lipid emulsions in very low birth weight infants showed lower very low-density lipoprotein and free carnitine levels. Olive oil emulsions resulted in higher free carnitine and lower hexanoyl carnitine, potentially impacting sepsis risk.

Area of Science:

  • Neonatal nutrition
  • Biochemistry
  • Pediatric intensive care

Background:

  • Parenteral nutrition is crucial for very low birth weight infants.
  • Lipid emulsions are a key component of parenteral nutrition.
  • Different lipid sources may have distinct metabolic effects.

Purpose of the Study:

  • To compare the impact of soybean oil versus olive oil-based lipid emulsions on plasma lipids and acylcarnitines in very low birth weight infants.
  • To investigate potential differences in metabolic profiles and clinical implications.

Main Methods:

  • A randomized comparative study involving 40 very low birth weight infants (≤32 weeks gestational age).
  • Infants received either soybean oil-based (Intralipid®) or olive oil-based (Clinoleic®) lipid emulsions.
  • Plasma lipid concentrations and acylcarnitine profiles were assessed.

Main Results:

  • No significant differences in triglyceride, cholesterol, HDL, or LDL levels between groups.
  • Lower very low-density lipoprotein levels were observed in the soybean oil group (p<0.05).
  • Significantly lower free carnitine and higher hexanoyl carnitine levels were found in the soybean oil group compared to the olive oil group.

Conclusions:

  • Soybean oil-based emulsions may influence lipid metabolism and carnitine status in VLBW infants.
  • Altered acylcarnitine profiles in the soybean oil group suggest potential impacts on mitochondrial fatty acid transport.
  • The findings highlight the need for careful selection of lipid emulsions in neonatal parenteral nutrition to optimize metabolic outcomes and potentially mitigate risks like sepsis.
Abstract

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