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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Cellular immune response parameters that influence IgE sensitization.

Pamela A Frischmeyer-Guerrerio1, John T Schroeder

  • 1The Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins Children's Hospital, Johns Hopkins University, USA.

Journal of Immunological Methods
|January 17, 2012
PubMed
Summary
This summary is machine-generated.

This review explores how basophil and dendritic cell (DC) assays help understand allergic disease mechanisms and evaluate immunomodulatory therapies for allergies.

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Last Updated: May 25, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Published on: June 29, 2021

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
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Published on: December 1, 2014

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • In vitro basophil responses are established tools for studying human allergic diathesis.
  • Dendritic cells (DCs) are emerging as valuable in evaluating immunomodulatory therapies for allergic diseases.

Purpose of the Study:

  • To review recent advances in assays utilizing basophils and DCs.
  • To highlight the combined utility of basophils and DCs in understanding allergic disease mechanisms.

Main Methods:

  • Review of current literature on basophil and dendritic cell assays.
  • Analysis of in vitro studies assessing immune responses in allergic conditions.

Main Results:

  • Basophil and DC assays provide insights into immune cell mechanisms in allergies.
  • These assays are crucial for evaluating the efficacy of immunomodulatory treatments.

Conclusions:

  • Both basophil and dendritic cell responses are key to understanding and treating allergic diseases.
  • Integrating data from both cell types offers a comprehensive view of allergic immune responses.