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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Treatment with carotid angioplasty stent placement for post-stroke depression compared to antidepressants

Heqing Huang1, Kangning Chen, Tianyou Guo

  • 1Department of Neurology of Southwest Hospital, Third Military Medical University, Chongqing, China.

Neurosciences (Riyadh, Saudi Arabia)
|January 17, 2012
PubMed

Insights

Carotid angioplasty with stenting (CAS) effectively treats post-stroke depression (PSD) in patients with high-grade carotid artery stenosis. CAS showed superior results to selective serotonin reuptake inhibitors (SSRIs) after one month.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Psychiatry

Background:

  • Post-stroke depression (PSD) is a common complication following cerebral ischemia.
  • High-grade carotid artery stenosis increases stroke risk and may contribute to PSD.
  • Effective management of PSD is crucial for neurological rehabilitation.

Purpose of the Study:

  • To compare the efficacy of carotid angioplasty with stenting (CAS) versus selective serotonin reuptake inhibitors (SSRIs) in treating PSD.
  • To evaluate the impact of CAS and SSRIs on neurological recovery in patients with high-grade carotid artery stenosis.

Main Methods:

  • A prospective, controlled study enrolled 182 patients with high-grade carotid artery stenosis and cerebral ischemia.
  • Patients were divided into two groups: CAS (n=104) and SSRIs (n=78).
  • The Hamilton Depression Rating Scale (HDRS) and National Institutes of Health Stroke Scale (NIHSS) were used for assessment at baseline, 1 month, and 3 months post-treatment.

Main Results:

  • The CAS group showed a significant decrease in NIHSS scores at 1 and 3 months post-treatment (p=0.007, p=0.006).
  • At 1 month, the CAS group had significantly lower HDRS scores compared to the SSRIs group (p=0.005).
  • No significant difference in HDRS scores was observed between the groups at 3 months.

Conclusions:

  • Carotid angioplasty with stenting (CAS) effectively alleviates post-stroke depression (PSD) in patients with high-grade carotid artery stenosis.
  • CAS also contributes to improved neurological rehabilitation in this patient population.
  • The therapeutic effect of CAS on PSD was superior to SSRIs at the one-month follow-up.
Abstract

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