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Sweet syndrome in an infant with chronic granulomatous disease

Jeffrey A Knipstein1, Daniel R Ambruso

  • 1Department of Pediatrics, Division of Hematology/Oncology/BMT, University of Colorado, Aurora †Bonfils Blood Center, Denver, CO, USA.

Journal of Pediatric Hematology/Oncology
|January 17, 2012
PubMed

Insights

Sweet syndrome, a painful skin condition, can occur in children with chronic granulomatous disease (CGD). This case highlights that Sweet syndrome may be part of the inflammatory spectrum in CGD patients.

Area of Science:

  • Dermatology
  • Pediatrics
  • Immunology

Background:

  • Sweet syndrome is an acute febrile neutrophilic dermatosis.
  • While more prevalent in adults, pediatric cases of Sweet syndrome are documented.
  • Chronic granulomatous disease (CGD) is a primary immunodeficiency predisposing individuals to recurrent infections and inflammatory disorders.

Observation:

  • A case report of an infant with known CGD is presented.
  • The infant experienced methicillin-sensitive Staphylococcus aureus lymphadenitis.
  • Following lymphadenitis, the infant developed symptoms consistent with Sweet syndrome.

Findings:

  • This report details a pediatric case of Sweet syndrome in a patient with chronic granulomatous disease.
  • Sweet syndrome presentation in this CGD infant was associated with a bacterial infection.
  • The occurrence suggests a potential link between CGD and Sweet syndrome development.

Implications:

  • This case expands the understanding of inflammatory conditions associated with CGD.
  • It suggests Sweet syndrome should be considered in the differential diagnosis of febrile neutrophilic dermatosis in CGD patients.
  • Further research may elucidate the mechanisms linking CGD and Sweet syndrome.

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