Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned under...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional gas exchange evaluation during ex vivo lung perfusion in a swine model of localized lung dysfunction.

Animal models and experimental medicine·2026
Same author

Recirculation Quantified by Trans-Extracorporeal Membrane Oxygenation Thermodilution to Predict Mixed Venous Oxygenation during Veno-venous Extracorporeal Membrane Oxygenation: An In Vivo Porcine Study.

Anesthesiology·2026
Same author

Albumin kinetics, intravascular fluid volume, and respiratory function in pigs ventilated at different levels of mechanical power following crystalloid vs. albumin infusion.

Intensive care medicine experimental·2026
Same author

<i>In vitro</i> characterization of hemoglobin oxygen dissociation curves and electrolyte shifts in human blood under varying PCO<sub>2</sub>.

Frontiers in medicine·2026
Same author

Biomarkers trajectories in critically ill patients with COVID-19 acute respiratory distress syndrome: insights from latent class growth analysis.

BMC pulmonary medicine·2025
Same author

Evaluation of a New Device for Clearing Secretions From Lower Airways.

Respiratory care·2025
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
Same journal

Airway ultrasound in patients undergoing head and neck surgery.

Current opinion in anaesthesiology·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

Towards ultraprotective mechanical ventilation.

Luciano Gattinoni1, Eleonora Carlesso, Thomas Langer

  • 1Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy. gattinon@policlinico.mi.it

Current Opinion in Anaesthesiology
|January 17, 2012
PubMed
Summary
This summary is machine-generated.

Lung stress and strain are key to ventilator-induced lung injury. Mechanical ventilation can be harmful at lower levels than expected due to lung inhomogeneity, necessitating lung rest strategies like extracorporeal support.

Related Experiment Videos

Last Updated: May 25, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

Area of Science:

  • Mechanical ventilation
  • Pulmonary physiology
  • Critical care medicine

Background:

  • Ventilator-induced lung injury (VILI) is a significant complication of mechanical ventilation.
  • Understanding the mechanical determinants of VILI, specifically lung stress and strain, is crucial for patient outcomes.

Purpose of the Study:

  • To review the causes of VILI, focusing on the mechanical factors of lung stress and strain.
  • To analyze the discrepancy between experimental and clinical findings regarding harmful ventilation parameters.

Main Methods:

  • Review of existing literature on VILI, mechanical ventilation, and lung physiology.
  • Analysis of stress and strain as determinants of VILI.
  • Discussion of lung inhomogeneity and its role in VILI.

Main Results:

  • Tidal volume and airway pressure are inadequate surrogates for lung strain and stress.
  • Lung inhomogeneity can create 'stress risers,' leading to VILI at lower volumes than predicted.
  • Lung protective strategies may involve reducing tidal volume, increasing airway pressure, or utilizing extracorporeal respiratory support.

Conclusions:

  • Extracorporeal respiratory support offers a method to reduce the mechanical load on the lungs, enabling lung rest when protective ventilation is insufficient.
  • This approach can be vital in managing severe VILI and improving outcomes in critically ill patients.