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Insulin sensitivity modifies the relationship between thyroid function and lipid profile in euthyroid type 1 diabetic
Tomislav Bulum1, Branko Kolarić, Lea Duvnjak
1Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Dugi dol 4a, Zagreb, Croatia. tbulum@idb.hr
Thyroid function may impact lipid levels in euthyroid (normal thyroid function) individuals with type 1 diabetes, particularly when insulin sensitivity is low. This suggests insulin sensitivity mediates thyroid hormone effects on cholesterol.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Research
Background:
- Dyslipidemia is common in hypothyroidism, but associations may exist even with normal thyroid function.
- Altered insulin sensitivity might link thyroid status to lipid changes in euthyroid individuals.
Purpose of the Study:
- To investigate insulin sensitivity as a mediator of thyroid hormone-induced lipid alterations.
- To analyze the relationship between thyroid function and lipid profiles in euthyroid type 1 diabetic patients.
Main Methods:
- Included 304 type 1 diabetic patients with normal thyroid function.
- Measured insulin sensitivity using estimated glucose disposal rate (eGDR).
- Assessed thyroid hormones (TSH, FT4, FT3) and serum lipids, performing correlation and regression analyses.
Main Results:
- Overall, thyroid hormones were not significantly associated with serum lipids, irrespective of insulin sensitivity.
- In patients with the lowest insulin sensitivity quartile, TSH showed an independent association with LDL cholesterol (p=0.02).
Conclusions:
- Altered insulin sensitivity may influence lipid metabolism in euthyroid individuals.
- Thyroid function's impact on lipids might extend to the euthyroid range, mediated by insulin sensitivity.
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