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The relationship between high-sensitivity C-reactive protein and ApoB, ApoB/ApoA1 ratio in general population of
Wanhua Xu1, Rong Li, Suhua Zhang
1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, Chongqing, 400016, China.
Insights
High-sensitivity C-reactive protein (hsCRP) indicates cardiovascular risk. Waist circumference, a measure of abdominal obesity, was a stronger predictor of hsCRP than apolipoprotein B (ApoB) or other cardiovascular risk factors.
Area of Science:
- Cardiovascular disease research
- Inflammation biomarkers
- Metabolic health
Background:
- High-sensitivity C-reactive protein (hsCRP) is a key predictor of cardiovascular events.
- Apolipoprotein B (ApoB) reflects atherogenic lipoproteins and may influence vascular inflammation.
Purpose of the Study:
- To investigate the association between ApoB and hsCRP.
- To determine if ApoB is a better predictor of inflammatory status than other cardiovascular risk factors.
Main Methods:
- Cross-sectional study of 511 healthy adults.
- Measurements included waist circumference, BMI, blood pressure, glucose, hsCRP, lipid profile, and insulin.
- Statistical analyses included Pearson's correlation and stepwise regression.
Main Results:
- hsCRP levels increased with higher BMI, waist circumference, blood pressure, insulin resistance, and triglycerides.
- hsCRP correlated with most variables except total cholesterol and LDL-C.
- Waist circumference was the strongest predictor of hsCRP, outperforming ApoB and other factors.
Conclusions:
- Abdominal obesity, indicated by waist circumference, is a primary driver of chronic inflammation.
- ApoB is associated with hsCRP but not its major determinant.
- Waist circumference is a more significant predictor of hsCRP than atherogenic dyslipidemia.
Abstract:
Inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) is considered as a major predictor of cardiovascular events. Apolipoprotein B (ApoB) directly reflects the number of plasma atherogenic lipoproteins, and may play a major role in vascular inflammation. We aimed to assess whether an association between ApoB and hsCRP exists and, furthermore, to examine whether ApoB is more predictive of the inflammatory status than other cardiovascular risk factors. This was a cross-sectional study, with 511 apparently healthy adult subjects enrolled. Waist circumference (WC), body mass index (BMI), and blood pressure (BP) were measured. Plasma glucose levels, hsCRP, lipid profile, and insulin were collected after 10-14 h fasting. From the lowest to the highest quartile of hsCRP, the values for BMI, WC, BP, HOMA-IR, insulin, glucose level, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), ApoB and the ApoB/apolipoprotein A1 (ApoA1) ratio were increased as the hsCRP level increased (P < 0.01), and high-density lipoprotein cholesterol (HDL-C) and ApoA1 levels declined as hsCRP level increased (P < 0.0001). Pearson's correlation analysis demonstrated that hsCRP correlated with all variables (P < 0.01), except for total cholesterol (TC) (P = 0.154) and LDL-C (P = 0.087). According to forward stepwise regression analysis with hsCRP as the dependent variable, WC was the only variable entered the regression model. ApoB level correlated with hsCRP level but was not the major determinant of hsCRP. WC was stronger than other cardiovascular risk factors in the associations with hsCRP. Abdominal obesity rather than atherogenic dyslipidemia was the primary cause of chronic inflammatory status.
