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Related Concept Videos

Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

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Related Experiment Video

Updated: May 25, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
06:37

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

Necrotizing myopathy: clinicoserologic associations.

Elizabeth Ellis1, Ju Ann Tan, Sue Lester

  • 1Royal Adelaide Hospital, Adelaide, Adelaide, South Australia, Australia.

Muscle & Nerve
|January 17, 2012
PubMed
Summary

Necrotizing myopathy (NM) is a distinct condition from idiopathic inflammatory myositis (IIM). NM is linked to systemic lupus erythematosus (SLE), hypertension, and diabetes mellitus, necessitating cardiovascular risk assessment.

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Area of Science:

  • Rheumatology
  • Neurology
  • Immunology

Background:

  • Necrotizing myopathy (NM) is characterized by myofiber necrosis and lacks inflammatory infiltrates, differentiating it from idiopathic inflammatory myositis (IIM).
  • Antibodies to signal recognition particle (SRP) are typically associated with IIM, not NM.

Purpose of the Study:

  • To delineate the clinical features and associated conditions of necrotizing myopathy (NM).
  • To investigate the incidence of malignancy in NM patients.

Main Methods:

  • Clinical data from 64 NM cases were analyzed.
  • Autoantibodies were measured in 23 NM patients' sera.
  • Malignancy incidence was assessed using the South Australian Cancer Registry.

Main Results:

  • NM patients exhibited male predominance, myalgias, and elevated creatine kinase (CK) levels compared to IIM.
  • A significant proportion of NM patients had co-existing systemic lupus erythematosus (SLE), hypertension, and diabetes mellitus.
  • No NM patients possessed SRP antibodies, and NM did not confer an altered risk for malignancy.

Conclusions:

  • Necrotizing myopathy (NM) is frequently associated with systemic lupus erythematosus (SLE), hypertension, and diabetes mellitus.
  • Cardiovascular risk assessment is crucial for NM patients, potentially guiding targeted interventions.