Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Procalcitonin-An Enigmatic Anxiolytic Biomarker.

JAMA network open·2026
Same author

Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same author

Diabetes and Immunosuppression Drive Distinct Patterns of <i>Candidozyma auris</i> Skin Colonization and Dissemination in Mice.

bioRxiv : the preprint server for biology·2026
Same author

Characterizing the in vitro and in vivo effect of bicarbonate on azithromycin activity against Acinetobacter baumannii.

PloS one·2026
Same author

β-Glucan chitosan particle provides cross-protection against multi-drug-resistant Candida auris.

NPJ vaccines·2026
Same author

Universal high-dose meropenem for antimicrobial-resistant Gram-negative infections: evidence or overreach?

European journal of hospital pharmacy : science and practice·2026

Related Experiment Video

Updated: May 25, 2026

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus
05:34

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Published on: June 6, 2025

Pathogenesis of mucormycosis.

Ashraf S Ibrahim1, Brad Spellberg, Thomas J Walsh

  • 1Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, University of California-Los Angeles, 1124 W Carson St., Torrance, CA 90502, USA. ibrahim@labiomed.org

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|January 17, 2012
PubMed
Summary

Mucormycosis is a serious fungal infection affecting immunocompromised individuals. New strategies are needed to combat this deadly disease, particularly focusing on iron acquisition by Rhizopus oryzae and host-pathogen interactions.

More Related Videos

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection
06:28

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection

Published on: November 27, 2014

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Related Experiment Videos

Last Updated: May 25, 2026

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus
05:34

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Published on: June 6, 2025

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection
06:28

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection

Published on: November 27, 2014

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Mucormycosis is a life-threatening fungal infection.
  • It primarily affects immunocompromised patients, including those with diabetic ketoacidosis, neutropenia, organ transplants, or high iron levels.
  • The increasing prevalence of underlying conditions like diabetes and cancer raises the number of at-risk individuals.

Purpose of the Study:

  • To review current knowledge on the virulence factors of Rhizopus oryzae, the main cause of mucormycosis.
  • To highlight the importance of iron acquisition and endothelial cell interactions in disease pathogenesis.
  • To identify potential targets for novel therapeutic interventions.

Main Methods:

  • Review of existing literature on mucormycosis pathogenesis and Rhizopus oryzae virulence.
  • Focus on the organism's ability to acquire iron and interact with host endothelial cells.
  • Identification of promising preclinical therapeutic strategies.

Main Results:

  • Rhizopus oryzae utilizes specific virulence traits to cause infection.
  • Elevated serum iron levels increase susceptibility to angioinvasive mucormycosis.
  • The organism's iron acquisition mechanisms and interaction with endothelial cells are critical.

Conclusions:

  • Understanding Rhizopus oryzae virulence and host response is key to developing new treatments.
  • Targeting iron acquisition and host-pathogen interactions may offer novel therapeutic avenues.
  • Promising preclinical strategies for mucormycosis treatment have been identified.