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Updated: May 25, 2026

Computer-assisted Large-scale Visualization and Quantification of Pancreatic Islet Mass, Size Distribution and Architecture
Published on: March 4, 2011
Pancreatic islet cell amyloidosis manifesting as a large pancreas
Mehmet Ruhi Onur1, Mehmet Yalnız, Ahmet Kursad Poyraz
1Department of Radiology, University of Firat, Firat Universitesi Hastanesi Rektorluk Kampusu, 23119 Elazig, Turkey 23119. ruhionur@yahoo.com
Abstract:
A 39-year-old female patient presented to our hospital with epigastric pain lasting for two months. Laboratory results showed impaired glucose tolerance. Ultrasonography of the patient showed a hypoechoic, diffusely enlarged pancreas. CT revealed a large pancreas, with multiple calcifications. On MRI, a diffusely enlarged pancreas was seen hypointense on both T1- and T2-weighted images with heterogeneous enhancement after gadolinium administration. A biopsy of the pancreas revealed primary amyloidosis of islet cells. Decreased signal on T1-weighted images without inflammation findings on CT and MRI were clues for the diagnosis.
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