Related Experiment Video
Updated: May 25, 2026

07:33
A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Huge simultaneous trichobezoars causing gastric and small-bowel obstruction
Fariborz Mansour-Ghanaei1, Mohammadrasoul Herfatkar, Massih Sedigh-Rahimabadi
1Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran.
Summary
This case report details a rare instance of Rapunzel syndrome in a young girl with trichobezoars. Endoscopy confirmed a large gastric trichobezoar causing partial obstruction.
Area of Science:
- Gastroenterology
- Pathology
Background:
- Bezoars are indigestible masses in the gastrointestinal tract, with types including phyto-, lacto-, and trichobezoars.
- While bezoars are common, multiple giant bezoars causing gastric and intestinal obstruction (Rapunzel syndrome) are exceptionally rare.
Observation:
- A young girl presented with symptoms of partial gastric and intestinal obstruction.
- Her medical history revealed long-standing trichophagia (hair-eating).
- Physical examination was largely unremarkable, with abdominal radiography showing gastric distension and air-fluid levels.
Findings:
- Endoscopic examination definitively diagnosed a massive gastric trichobezoar.
- The trichobezoar was large enough to fill the stomach lumen and extend into the small intestine.
Implications:
- This case highlights the potential for trichobezoars, even in seemingly healthy individuals, to cause severe gastrointestinal obstruction.
- Early recognition of trichophagia and prompt endoscopic evaluation are crucial for managing such rare but serious conditions.
- Understanding the pathogenesis of bezoars is vital for developing effective prevention and treatment strategies.
Related Concept Videos
Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Intestinal Obstruction I: Introduction
Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Intestinal Obstruction II: Pathophysiology
Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Gastrointestinal Motility Disorders
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Esophageal Strictures-I: Introduction
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Achalasia
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

