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Fast disintegrating tablets: Opportunity in drug delivery system
Ved Parkash1, Saurabh Maan, Deepika
1Department of Pharmaceutics, B. S. Anangpuria Institute of Pharmacy, Alampur, Faridabad, India.
Journal of Advanced Pharmaceutical Technology & Research
|January 17, 2012
Summary
Fast disintegrating tablets (FDTs) offer a convenient oral drug delivery method, dissolving rapidly in the mouth without water. This technology improves patient compliance, especially for pediatric and geriatric populations.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Oral drug delivery is the most preferred route for drug administration.
- Fast disintegrating tablets (FDTs) are gaining popularity due to improved patient compliance and convenience.
- FDTs disintegrate rapidly in the oral cavity without the need for water.
Purpose of the Study:
- To review various formulations and technologies for FDTs.
- To discuss methods for enhancing FDT properties.
- To cover taste-masking and disintegration/dissolution measurements.
Main Methods:
- Review of existing literature on FDT technologies.
- Detailed discussion of lyophilization, molding, sublimation, and compaction techniques.
- Exploration of spray drying and disintegrant use for property enhancement.
Main Results:
- Several FDT technologies have been developed, including lyophilization, molding, sublimation, and compaction.
- Techniques like spray drying and the use of disintegrants can enhance FDT properties.
- Taste-masking and methods for measuring disintegration and dissolution are also discussed.
Conclusions:
- FDTs represent a significant advancement in oral drug delivery, offering ease of administration.
- The reviewed technologies provide effective solutions for developing water- and chewable-free disintegrating tablets.
- Further research in taste-masking and optimization of disintegration/dissolution is crucial for FDT development.
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