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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Bioactive compounds with effects on inflammation markers in humans.
Flávia Troncon Rosa1, M Ángeles Zulet, Julio Sérgio Marchini
1Division of Clinical Nutrition, Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Calle Irunlarrea 1, São Paulo, Brazil.
International Journal of Food Sciences and Nutrition
|January 18, 2012
Summary
Chronic inflammation, linked to obesity and metabolic syndrome, can be targeted by bioactive compounds. This review explores dietary factors like polyphenols and others that show anti-inflammatory effects in humans.
Area of Science:
- Nutrition Science
- Immunology
- Metabolic Health
Background:
- Obesity and metabolic syndrome are associated with chronic low-grade inflammation in multiple tissues.
- This inflammation involves increased inflammatory cytokines and immune cell infiltration, impairing insulin signaling and increasing cardiovascular risk.
Purpose of the Study:
- To systematically review and discuss scientific literature on the anti-inflammatory effects of various bioactive compounds in humans.
- To identify dietary patterns, foods, and specific compounds with protective anti-inflammatory actions relevant to chronic diseases.
Main Methods:
- Systematic scientific literature search.
- Collection and discussion of relevant studies on bioactive compounds and inflammation in humans.
Main Results:
- Polyphenols, particularly isoflavones and anthocyanins, are extensively studied for their anti-inflammatory properties.
- Other investigated compounds include quercetin, catechin, resveratrol, milk peptides, plant sterols/stanols, l-carnitine, and alpha-lipoic acid.
Conclusions:
- Bioactive compounds found in foods show potential for mitigating inflammation associated with obesity and metabolic syndrome.
- Further research and dietary interventions focusing on these compounds may offer protective strategies against chronic diseases and cardiovascular events.
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