Related Experiment Video
Updated: May 25, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Psychosocial therapeutic interventions for volatile substance use: a systematic review
Sarah MacLean1, Jacqui Cameron, Angela Harney
1Turning Point Alcohol and Drug Centre, Fitzroy, Victoria, Australia. sarah.maclean@turningpoint.org.au
Aims:
Volatile substance use (VSU) is associated with a range of adverse outcomes, including cognitive impairment and death. It occurs disproportionately within young and marginalized populations. A previous international systematic review of VSU treatment identified no relevant studies. This paper reports on a systematic review of a range of study types concerning psychosocial interventions for VSU.
Methods:
Search parameters were developed using the Population, Intervention, Professionals, Outcomes, Health care setting and Contexts (PIPOH) tool with input from an expert committee. Included were randomized controlled trials (RCTs), comparative studies with or without concurrent controls, case series studies and grey literature, published in English during 1980-2010.
Results:
The initial search identified 2344 references. After two screening phases, 23 studies of VSU therapeutic interventions remained. Of these, 19 concerned psychosocial interventions, which we discuss as: case management; counselling; recreation and engagement programmes; and residential treatment. Studies were conducted in Australia, Canada, the United States, United Kingdom and Brazil. No RCTs were identified and studies were generally of low evidentiary levels.
Conclusions:
Even when a range of study types are included, clear conclusions for volatile substance use psychological treatment are not supported, but three intervention types merit further examination: family therapy, activity-based programmes and Indigenous-led residential approaches. Future volatile substance use research could be enhanced by developing and validating outcome measurement tools. Robust multi-site studies are also required.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
CNS Depressants: Alcohol and Nicotine
Drug Therapy
Antianxiety Medications
Pharmaceutical Poisoning: Treatment Strategies
Community Based Intervention
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...

