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Near-Infrared Spectroscopy During Reactive Hyperemia for the Assessment of Lower Limb Vascular Function

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Syncope and Raynaud's disease.

Roberto J Guiloff¹, Sanjeev Rajakulendran, Heather Angus-Leppan

¹West London Neurosciences Centre, Charing Cross Hospital, Imperial College Healthcare National Health Service Trust, London, England. r.guiloff@imperial.ac.uk

Archives of Neurology

|January 18, 2012

Summary

This summary is machine-generated.

Recurrent syncope in patients with Raynaud's disease (RD) is not due to chance or migraine. Nifedipine treatment effectively stopped syncope, suggesting brainstem ischemia as a cause and warranting screening for RD in unexplained syncope cases.

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Area of Science:

Neurology
Vascular Medicine
Clinical Research

Background:

Raynaud's disease (RD) is a condition characterized by vasospasm in extremities.
Syncope, or fainting, can have various underlying causes.
The potential association between RD and syncope requires further investigation.

Purpose of the Study:

To explore the link between syncope and Raynaud's disease.
To identify clinical features associated with this syncope.
To evaluate the efficacy of nifedipine in treating syncope in RD patients.

Main Methods:

A prospective study involving new outpatients with syncope and suspected RD.
Clinical observations and follow-up over a defined period.
Assessment of the temporal relationship between syncope and Raynaud's phenomenon, and response to nifedipine.

Main Results:

An increased frequency of syncope was observed in patients with RD (1.3%) compared to expected.
Syncope was often preceded or occurred concurrently with Raynaud's phenomenon.
Nifedipine treatment successfully resolved syncope in all affected patients.

Conclusions:

The association between syncope and RD is statistically significant and not attributable to chance or migraine.
Brainstem ischemia is a potential mechanism for syncope in RD.
Screening for Raynaud's disease is recommended for patients presenting with unexplained recurrent syncope.