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Updated: May 25, 2026
05:46
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
HIV-associated kidney glomerular diseases: changes with time and HAART
François-Xavier Lescure1, Clara Flateau, Jérôme Pacanowski
1Department of Infectious and Tropical Diseases, Tenon Hospital, AP-HP, Paris, France.
Summary
Focal segmental glomerulosclerosis (FSGS) is now the leading glomerular disease in human immunodeficiency virus (HIV)-infected patients, surpassing HIV-associated nephropathy (HIVAN). Classic FSGS is linked to cardiovascular risk factors, while HIVAN is associated with severe kidney failure.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- HIV treatment and comorbidities have evolved, impacting renal complications in patients.
- Glomerular disease distribution in HIV patients requires updated assessment.
Purpose of the Study:
- To evaluate changes in the prevalence of glomerular diseases among HIV-infected individuals.
- To compare the characteristics of different glomerular disease types in HIV patients.
Main Methods:
- Retrospective analysis of 88 HIV patients with biopsy-proven glomerular disease (1995-2007).
- Inclusion of demographic, clinical, laboratory, and renal histopathological data.
Main Results:
- HIV-associated nephropathy (HIVAN) decreased over time.
- Classic focal segmental glomerulosclerosis (FSGS) emerged as the most common glomerular disease (46.9%) in recent years (2004-07).
- HIVAN strongly associated with Black race, low CD4 count, and severe renal failure; classic FSGS linked to longer infection duration, HCV co-infection, and cardiovascular risk factors.
Conclusions:
- Classic FSGS, associated with metabolic and cardiovascular risk factors, now predominates over HIVAN in HIV patients.
- HIVAN remains a significant cause of severe renal failure, particularly in Black patients with low CD4 counts.
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