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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

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Updated: May 25, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Neuroblastoma.

Andrew M Davidoff1

  • 1Department of Surgery, St Jude Children's Research Hospital, Memphis, Tennessee, USA. andrew.davidoff@stjude.org

Seminars in Pediatric Surgery
|January 18, 2012
PubMed
Summary
This summary is machine-generated.

Neuroblastoma tumor behavior varies greatly. Understanding its molecular genetics improves risk assessment and guides new targeted therapies for improved outcomes in children with this cancer.

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Area of Science:

  • Pediatric Oncology
  • Cancer Genetics
  • Molecular Biology

Background:

  • Neuroblastoma is a diverse childhood cancer with unpredictable clinical behavior.
  • Tumor biology significantly influences prognosis and treatment strategies.
  • Current risk stratification relies on clinical and biological factors to predict relapse.

Purpose of the Study:

  • To review recent advances in understanding neuroblastoma molecular pathogenesis.
  • To discuss the impact of molecular insights on current risk stratification.
  • To identify potential therapeutic targets for neuroblastoma.

Main Methods:

  • Literature review of recent advances in neuroblastoma research.
  • Analysis of molecular genetic events in neuroblastoma pathogenesis.
  • Review of recent clinical trial outcomes for neuroblastoma treatment.

Main Results:

  • Molecular genetic events are crucial in neuroblastoma development and progression.
  • Biological and molecular features are highly predictive of clinical behavior.
  • Risk stratification is increasingly informed by molecular data.

Conclusions:

  • Advances in molecular genetics are refining neuroblastoma risk assessment.
  • Molecular targets offer promising avenues for novel therapeutic approaches.
  • Personalized treatment strategies are evolving based on tumor biology.