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07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Multiple brown tumors causing spinal cord compression in association with secondary hyperparathyroidism
Sônia M H A Araújo1, Veralice M S Bruin, Andrew S Nunes
1Department of Internal Medicine, Federal University of Ceará, Rua Professor Costa Mendes, no 2609, Fortaleza, CE, CEP 60430-040, Brazil. sholanda.almeidaaraujo@gmail.com
International Urology and Nephrology
|January 18, 2012
Summary
Brown tumors, a rare complication of secondary hyperparathyroidism, can cause spinal cord compression. This case highlights the importance of considering brown tumors in patients with renal disease experiencing neurological deficits.
Area of Science:
- Nephrology
- Endocrinology
- Neurology
Background:
- Brown tumors are non-neoplastic lesions resulting from excess osteoclast activity.
- They are associated with primary hyperparathyroidism (HPTP) and secondary hyperparathyroidism (HPTS).
Observation:
- A 47-year-old male with end-stage renal disease and severe HPTS developed paraplegia.
- Imaging revealed brown tumors compressing the spinal cord at the sacral and thoracic levels.
Findings:
- Histopathological analysis confirmed brown tumor with osteoid tissue, fibroplasia, and hemosiderin.
- Surgical excision of the thoracic lesion was performed.
Implications:
- Sudden neurological deficits in renal patients with secondary hyperparathyroidism may indicate spinal cord compression by brown tumors.
- Early consideration of brown tumors in the differential diagnosis is crucial for timely intervention and management.
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