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Updated: May 25, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
[Side effects of tumor pharmacotherapy. What internists should know]
1Klinik für Hämatologie, Onkologie, Immunologie, Zentrum Innere Medizin, Philipps Universität Marburg und Universitätsklinikum Gießen und Marburg, Standort Marburg, Baldingerstrasse 1, Marburg, Germany. wollmer@med.uni-marburg.de
Abstract:
Cytotoxic drugs have been used in the therapy of malignant tumors for the last 70 years. However, side effects of cytotoxic drugs are very common and often dose-limiting. Although many protocols have been optimized, side effects are still frequently life-threatening. Nausea and vomiting are among the most frequently reported side effects, in addition to mucositis and fatigue. Bone marrow toxicity can lead to neutropenic sepsis, thrombocytopenic bleeding, or anemia with the respective sequelae. In addition to these unspecific side effects, organ toxicity is class or drug specific and may involve the kidney, liver, heart, lung, skin, or central nervous system. As most protocols can be administered on an outpatient basis, knowledge of these side effects is important for the general internist.
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