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Published on: June 10, 2025
Temporal variation of heart failure hospitalization: does it exist?
Benedetta Boari1, Elisa Mari, Massimo Gallerani
1Department of Internal Medicine, University of Ferrara, Italy.
Insights
Congestive heart failure (CHF) hospitalizations and deaths may peak in winter, on Mondays, and at night. These patterns align with known temporal variations in major cardiovascular events.
Area of Science:
- Cardiology
- Public Health
- Chronobiology
Background:
- Congestive heart failure (CHF) is a significant global health concern, representing the final stage of various cardiac conditions.
- Coronary heart disease and hypertension are primary etiological factors contributing to CHF.
- Major acute cardiovascular events exhibit non-random temporal patterns, including seasonal (winter), weekly (Monday), and circadian (morning) predispositions.
Purpose of the Study:
- To investigate the temporal variations in congestive heart failure (CHF) hospitalization and mortality.
- To determine if CHF events align with the established temporal patterns of acute cardiovascular events.
Main Methods:
- Analysis of hospitalization and mortality data for congestive heart failure.
- Statistical examination of temporal trends, including seasonal, weekly, and circadian patterns.
- Comparison of CHF event timing with known cardiovascular event chronotypes.
Main Results:
- Evidence suggests a potential preference for congestive heart failure hospitalizations and mortality during winter months.
- Findings indicate a possible increase in CHF events on Mondays.
- The study points to a potential nighttime predilection for congestive heart failure events.
Conclusions:
- The temporal patterns observed in congestive heart failure hospitalizations and mortality may be influenced by the underlying etiology.
- Understanding these temporal variations could inform public health strategies and clinical interventions for CHF management.
- Further research is warranted to elucidate the mechanisms behind the observed chronobiological patterns in CHF.
Abstract:
Congestive heart failure (CHF) is the end stage of many cardiac diseases, and one of the leading causes of mortality and morbidity around the world. Coronary heart disease and hypertension (either singly or together) are the main etiology for CHF. It has been reported that major acute cardiovascular events (myocardial infarction, sudden death, cardiac arrest, ischemic and hemorrhagic stroke, pulmonary embolism, rupture/dissection of aortic aneurysms) do not occur randomly through time, but exhibit a specific temporal periodicity characterized by seasonal (winter), weekly (Monday), and circadian (morning) patterns of onset. Thus, because the major causes of CHF present a temporal pattern, in the past several years some studies have investigated the temporal variation of CHF hospitalization and mortality, with results indicating the possibility of a preference for winter months, Mondays, and nighttime, respectively.
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