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Initial experience with bendamustine in patients with recurrent primary central nervous system lymphoma: a case
Jaclyn J Renfrow1, Alisha Detroye, Michael Chan
1Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Journal of Neuro-Oncology
|January 18, 2012
Summary
Bendamustine shows promise for recurrent primary central nervous system lymphoma (RPCNSL). This therapy was well-tolerated, with one patient achieving stable disease for over 20 months post-treatment.
Area of Science:
- Neuro-oncology
- Pharmacology
Background:
- Recurrent primary central nervous system lymphoma (RPCNSL) requires novel therapeutic strategies.
- Bendamustine, an alkylating agent, is approved for systemic lymphomas and may cross the blood-brain barrier.
Observation:
- This report details the initial use of bendamustine in RPCNSL patients.
- Treatment was generally well-tolerated.
Findings:
- One patient achieved stable disease after eight cycles of bendamustine.
- Central nervous system involvement remained stable for over 20 months post-treatment, despite a later systemic recurrence.
Implications:
- Bendamustine demonstrates potential as a treatment for RPCNSL.
- Further neuropharmacokinetic and efficacy studies are warranted for this patient population.
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