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Updated: May 25, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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[Update on interstitial brachytherapy].

T Bretschneider1, N Peters, P Hass

  • 1Zentrum für Radiologie, Klinik für Radiologie und Nuklearmedizin, Klinikum A.ö.R. der Otto-von-Guericke-Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland. tina.bretschneider@med.ovgu.de

Der Radiologe
|January 18, 2012
PubMed
Summary
This summary is machine-generated.

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Image-guided brachytherapy offers a safe and effective minimally invasive oncologic treatment. This technique overcomes thermal ablation limitations, showing high local tumor control rates for various cancers.

Area of Science:

  • Oncology
  • Radiology
  • Medical Physics

Background:

  • Minimally invasive treatments like image-guided local tumor ablation are increasingly vital in oncology.
  • Thermal ablation methods (e.g., RFA, LITT) have limitations concerning maximum tumor size, cooling effects from adjacent vessels, and proximity to critical structures.

Purpose of the Study:

  • To evaluate the efficacy and safety of percutaneous, computed tomography (CT)-guided brachytherapy as an alternative to thermal ablation.
  • To highlight the advantages of brachytherapy in overcoming the limitations of thermal ablation techniques.

Main Methods:

  • Percutaneous, CT-guided interstitial brachytherapy utilizing high-dose rate (HDR) irradiation.
  • Application of a steep dose gradient to minimize radiation exposure to surrounding healthy tissues.

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Main Results:

  • Achieved local tumor control rates of approximately 90% at 12 months for hepatocellular carcinoma (HCC) and 70-90% for colorectal cancer (CRC) liver metastases, cholangiocarcinoma (CCC), and other metastatic cancers (RCC, NSCLC, neuroendocrine tumors).
  • Demonstrated efficacy irrespective of tumor location, without limitations from cooling effects.
  • Successfully applied in over 5,000 cases, indicating established clinical utility.

Conclusions:

  • Image-guided brachytherapy is a safe and effective oncologic treatment modality.
  • The technique has been integrated into routine clinical practice, offering a viable alternative to thermal ablation.