Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
The Physiology of Taste01:24

The Physiology of Taste

The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the diffusion of...
Gustation01:43

Gustation

Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles.

Cell reports·2026
Same author

Opposing gastric and jejunal regulation of CELA2A in obesity and after Roux-en-Y gastric bypass suggests a role in gastrointestinal metabolic signaling.

Frontiers in endocrinology·2026
Same author

Tracing the impact of electrophysiological studies of magnocellular neurons.

Progress in neurobiology·2026
Same author

Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner.

Translational psychiatry·2026
Same author

The Role of Digital Tools and Their Implementation Within Patient Care Pathways for Rare Brain Disorders: The Case of Phenylketonuria.

European journal of neurology·2026
Same author

Electrophysiological recording of hypothalamic brain regions in vivo using the transpharyngeal surgical approach in the rat.

Journal of neuroendocrinology·2026

Related Experiment Video

Updated: May 25, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

Peripheral signals modifying food reward.

John R W Menzies1, Karolina P Skibicka, Emil Egecioglu

  • 1Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Scotland, UK. john.menzies@ed.ac.uk

Handbook of Experimental Pharmacology
|January 18, 2012
PubMed
Summary
This summary is machine-generated.

Eating pleasure involves complex brain pathways connecting energy balance and reward. Peripheral neuropeptides, typically linked to appetite, also regulate these hedonic feeding aspects.

More Related Videos

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

Related Experiment Videos

Last Updated: May 25, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

Area of Science:

  • Neuroscience
  • Metabolic Regulation
  • Appetite Control

Background:

  • The pleasure of eating is a complex process.
  • It involves central pathways linking energy homeostasis and reward.
  • Metabolic and endocrine factors regulate these pathways.

Purpose of the Study:

  • To describe the significance of reward in feeding.
  • To outline the neural substrates of the reward pathway.
  • To explain how peripheral peptides modify these pathways.

Main Methods:

  • Review of existing literature on feeding reward.
  • Analysis of neural pathways involved in appetite control.
  • Examination of peripheral neuropeptide effects on hedonic feeding.

Main Results:

  • Reward plays a significant role in the decision to eat.
  • Central pathways integrate energy balance and reward.
  • Peripheral neuropeptides influence the hedonic aspects of feeding.

Conclusions:

  • Hedonic feeding is regulated by a complex interplay of central and peripheral factors.
  • Neuropeptides traditionally associated with homeostatic appetite control also modulate feeding reward.
  • Understanding these pathways is crucial for addressing eating behaviors.