[1:2 matched case-control study of congenital deficiency of newborn]

Among 5959 perinatal newborn, 135 cases of congenital deficiency were detected. The frequency was 22.66 per 1,000 newborns. In order to explore possible factors related to congenital deficiency, for 103 cases a 1:2 matched case-control study was performed. Mantel-Haentel chi 2 test and conditional logistic regression model was used to identify factors which associated with the disease significantly in statistics. It was found that six factors, i.e. common cold and fever in the early stage of pregnancy, illiteracy of mother, family history of congenital disease, haemorrhage of genital tract, alcohol drinking and marriage within blood relatives, are risk factors related to congenital deficiency of newborn.