Related Experiment Video

Updated: May 25, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency

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[Enhanced serum DNAase activity in hypersensitization to pollen allergens]

L V Khripach, A K Makovetskaia, V N Fedoseeva

    Gigiena I Sanitariia
    |January 19, 2012
    PubMed

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    Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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    Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
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