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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

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Related Experiment Video

Updated: May 25, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Rising incidence of Merkel cell carcinoma.

Dorte Lyhne1, Jørgen Lock-Andersen, Karin Dahlstrøm

  • 1Department of Plastic Surgery, Rigshospitalet, Copenhagen. Dortelyhne@hotmail.com

Journal of Plastic Surgery and Hand Surgery
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma (MCC), a rare and aggressive skin cancer, is increasing in incidence, particularly in those over 65. Optimal treatment guidelines are proposed, including surgery, imaging, and radiotherapy.

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Last Updated: May 25, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Area of Science:

  • Oncology
  • Dermatology
  • Epidemiology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with rising incidence.
  • Optimal treatment strategies for MCC remain undefined.
  • The histogenesis of MCC is not fully understood.

Purpose of the Study:

  • To evaluate staging, investigation, treatment, and follow-up of MCC in eastern Denmark.
  • To investigate the incidence of MCC.
  • To propose evidence-based treatment guidelines for MCC.

Main Methods:

  • Retrospective review of 51 MCC patient records (1995-2006) in eastern Denmark.
  • Analysis of nationwide MCC incidence data (1986-2003) from the Danish Cancer Registry.
  • MEDLINE search for relevant published literature on MCC.

Main Results:

  • MCC incidence increased 5.4-fold from 1986 to 2003, with highest rates in individuals over 65.
  • Recurrence was observed in 14 of 51 patients; 73% died during the study period.
  • Recommended treatment involves wide excision, sentinel lymph node biopsy, CT/PET imaging, and adjuvant radiotherapy.

Conclusions:

  • There is a significant increase in MCC incidence, necessitating standardized management protocols.
  • Proposed guidelines include comprehensive staging, surgical resection with adjuvant radiotherapy, and consideration of chemotherapy for advanced disease.
  • Prospective multicenter studies are crucial for evaluating MCC staging and treatment efficacy.