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Related Concept Videos

Vascular Spasm01:16

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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Pericarditis I: Introduction01:22

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Related Experiment Video

Updated: May 25, 2026

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
05:53

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

Published on: March 4, 2016

Fortuitous vasculitis.

Hema Sharma1, Ashvini Keshavan, Mark Alan Little

  • 1Department of Infectious Diseases, The Royal Free Hospital, London, UK. h.sharma@imperial.ac.uk

Renal Failure
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

This case highlights a rare instance of pauci-immune necrotizing crescentic glomerulonephritis linked to Mycobacterium fortuitum endocarditis in a patient with a cardiac device. Early suspicion and comprehensive diagnostics are crucial for managing occult infections.

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Last Updated: May 25, 2026

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
05:53

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

Published on: March 4, 2016

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Cardiology

Background:

  • A 43-year-old male with a cardiac device for dilated cardiomyopathy presented with constitutional symptoms and multi-organ dysfunction.
  • Initial investigations revealed pancytopenia, acute renal failure, pulmonary abnormalities, and elevated inflammatory markers.

Observation:

  • Renal biopsy showed pauci-immune necrotizing crescentic glomerulonephritis, leading to a diagnosis of antineutrophil cytoplasmic antibody-negative systemic small vessel vasculitis.
  • Despite initial immunosuppressive therapy, the patient developed neutropenic sepsis, influenza, and invasive aspergillosis.
  • Echocardiography identified a vegetation on the cardiac device's pacing wire, which cultured Mycobacterium fortuitum.

Findings:

  • The vegetation confirmed M. fortuitum endocarditis, a pathogen previously identified in bone marrow and blood cultures.
  • The patient's condition deteriorated despite device removal and antimicrobial treatment, ultimately succumbing to treatment-related complications.

Implications:

  • This is the first reported case of pauci-immune necrotizing crescentic glomerulonephritis associated with M. fortuitum endocarditis.
  • Clinicians must maintain a high index of suspicion for endocarditis in patients with cardiac devices presenting with fever and glomerulonephritis.
  • Comprehensive investigations including mycobacterial blood cultures, standard blood cultures, and echocardiography are essential. Caution is advised with immunosuppression in occult sepsis.