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Updated: May 25, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Recent developments in MS for small molecules: application to human doping control analysis.

Oscar J Pozo¹, Josep Marcos, Jordi Segura

¹Bioanalysis Research Group, IMIM, Hospital del Mar, Doctor Aiguader 88, 08003 Barcelona, Spain. opozo@imim.es

|January 19, 2012

Summary

This summary is machine-generated.

Mass spectrometry (MS) advances enhance doping control analysis for small molecules. New hyphenated MS techniques address limitations in detecting doping agents, improving analytical capabilities.

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Area of Science:

Analytical Chemistry
Forensic Science
Biochemistry

Background:

Mass spectrometry (MS) is crucial for doping control analysis.
Analytical requirements for detecting doping agents vary by substance.
Established MS approaches have achievements and drawbacks.

Purpose of the Study:

To review recent developments in MS for small molecule detection in doping control.
To discuss how new MS techniques can overcome limitations of current methods.
To explore future trends and remaining challenges in the field.

Main Methods:

Review of established and emerging mass spectrometry techniques.
Focus on hyphenated MS methods, including GC-MS/MS and LC-MS/MS.
Analysis of interfaces and analyzers in new MS developments.

Main Results:

Doping control analysis is evolving with MS technology.
New hyphenated MS techniques offer potential to minimize limitations.
Specific analytical requirements drive the choice of MS methods.

Conclusions:

Advancements in MS, particularly hyphenated techniques, are vital for doping control.
Ongoing development is needed to address remaining limitations in detecting doping agents.
The field is progressing towards more sensitive and specific analytical solutions.