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Updated: May 25, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis
Katherine Gordon1, Maria Miteva, Daniele Torchia
1Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami 33125, USA.
Abstract:
We describe a 64-year-old man with past chronic myeloid leukemia. Palisading neutrophilic granulomatous dermatitis of the hands was diagnosed and related to recent allopurinol intake. Allopurinol is known to rarely cause granulomatous reactions, but this appears to be the first case of palisading neutrophilic granulomatous dermatitis induction. Possible mechanisms include immune complex deposition, an immune response directed against the metabolites of allopurinol, or allopurinol hypersensitivity exclusively localized to the skin.
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