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Cerebral vasospasm.

R H Wilkins1

  • 1Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710.

Critical Reviews in Neurobiology
|January 1, 1990
PubMed
Summary

Cerebral vasospasm, narrowing of brain arteries after aneurysm rupture, can cause neurological deficits. Current management focuses on blood volume and blood pressure, with ongoing research into drug therapies.

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Area of Science:

  • Neurology
  • Vascular Surgery

Background:

  • Cerebral vasospasm involves intracranial arterial narrowing, often following subarachnoid hemorrhage.
  • It can manifest as arteriographic narrowing or delayed neurological deficits due to brain ischemia.
  • This condition typically arises after intracranial aneurysm rupture and can lead to cerebral infarction.

Purpose of the Study:

  • To define cerebral vasospasm and its clinical manifestations.
  • To review current understanding of its pathogenesis and treatment.
  • To highlight ongoing research in therapeutic interventions.

Main Methods:

  • Review of definitions and clinical presentations of cerebral vasospasm.
  • Analysis of etiological factors and pathogenetic mechanisms.
  • Evaluation of current and investigational treatment strategies.

Main Results:

  • Cerebral vasospasm is characterized by arterial narrowing and potential neurological deficits.
  • The condition typically occurs 2-3 weeks post-aneurysm rupture and can result from head trauma.
  • Pathogenesis remains unclear, with many treatments proving ineffective.

Conclusions:

  • Effective management includes maintaining adequate blood volume and blood pressure.
  • Calcium channel blockers are being investigated for improving cerebral circulation.
  • Further research is needed to clarify pathogenesis and develop novel treatments.

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