Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

Viral Hepatitis I: Introduction

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

Hypothyroidism II: Pathophysiology

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Incidental Finding of Thyroid Tuberculosis by Operation for Graves' Disease: A Rare Case Presentation.

Case reports in endocrinology·2024

Same author

Tamoxifen- and Triptorelin-Induced Major Hypertriglyceridemia: A Case Report.

Cureus·2024

Same author

Pheochromocytoma in an Ectopic Adrenal Gland.

Cureus·2023

Same author

Rare Cases of Hibernomas Associated With Bilateral Pheochromocytoma: A Report of Two Cases.

Cureus·2023

Same author

The Etiological Profile of Adrenal Incidentalomas.

Cureus·2023

Same author

Voluminous craniopharyngioma evolving since childhood revealed by a torticollis.

Journal of family medicine and primary care·2023

Search research articles

Related Experiment Video

Updated: May 25, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

[Thyroid and hepatitis C].

Hanan El Ouahabi¹, Farida Ajdi

¹CHU Hassan II, service d'endocrinologie, Fès, Maroc. hanan.elouahabi@gmail.com

Presse Medicale (Paris, France : 1983)

|January 19, 2012

Summary

Autoimmune thyroid diseases involve genetic, epigenetic, and environmental factors. Interferon-alpha (IFNa) therapy for Hepatitis C Virus (HCV) may trigger thyroiditis, though its link to chronic HCV infection requires further study.

Area of Science:

Endocrinology
Immunology
Virology

Context:

Autoimmune thyroid diseases (AITDs) arise from complex genetic, epigenetic, and environmental interactions.
Chronic Hepatitis C Virus (HCV) infection is a global health concern.
Interferon-alpha (IFNa) is a treatment for chronic HCV infection.

Purpose:

To explore the association between IFNa therapy for chronic HCV infection and the development of thyroiditis.
To investigate the debated relationship between thyroiditis and chronic HCV infection itself.

Summary:

IFNa therapy in chronic HCV patients is linked to subclinical or clinical thyroiditis.
The direct causal relationship between chronic HCV infection and thyroiditis remains under investigation.
This highlights potential immune-mediated effects of IFNa therapy on thyroid function.

More Related Videos

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Related Experiment Videos

Last Updated: May 25, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Impact:

Understanding these associations can inform clinical management of HCV patients undergoing IFNa therapy.
Further research may clarify the immunopathogenesis of thyroid dysfunction in viral infections.
This knowledge can contribute to improved patient care and monitoring strategies for thyroid health in HCV patients.