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Related Experiment Video

Updated: May 25, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

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Published on: May 8, 2018

Strategy for synchronous and multiple liver metastasis.

Shinji Osada1, Hisashi Imai, Yoshiyuki Sasaki

  • 1Gifu University School of Medicine, Gifu, Japan. sting@gifu-u.ac.jp

Hepato-Gastroenterology
|January 19, 2012
PubMed
Summary

Resection of colorectal cancer (CRC) liver metastases is complex. Neoadjuvant chemotherapy can be safely used before hepatectomy, without increasing complications, aiding in radical operation planning.

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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Colorectal Cancer Management

Background:

  • Surgical indications for resecting synchronous colorectal cancer (CRC) liver metastases remain debated.
  • Optimal timing for hepatectomy in these cases is controversial.

Purpose of the Study:

  • To evaluate the safety and efficacy of neoadjuvant chemotherapy followed by hepatectomy for synchronous colorectal cancer liver metastases.
  • To analyze recurrence rates and early detection after simultaneous versus staged hepatectomy.

Main Methods:

  • Retrospective analysis of 57 patients with synchronous liver metastases from CRC treated since May 2005.
  • Hepatectomy performed for resectable tumors; neoadjuvant chemotherapy used for unresectable cases with planned radical operation.
  • Comparison of simultaneous resection versus staged hepatectomy after chemotherapy.

Main Results:

  • Recurrence after hepatectomy was 75.0% for simultaneous and 70.0% for staged resections.
  • Early detection of recurrence post-resection was higher in simultaneous (58.3%) versus staged (14.2%) cases.
  • Neoadjuvant chemotherapy did not increase postoperative complications or surgical difficulty.

Conclusions:

  • Neoadjuvant chemotherapy is a safe option for selected patients with colorectal cancer liver metastases.
  • Staged hepatectomy may allow for better early detection of recurrence compared to simultaneous resection.