Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Nervous Tissue

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

Excitatory and Inhibitory Effects of Neurotransmitters

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Parkinson Disease ll: Pathophysiology

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons.

Cell·2025

Same author

Development of GABAergic Interneurons in the Human Cerebral Cortex.

The European journal of neuroscience·2025

Same author

Regulation of PV interneuron plasticity by neuropeptide-encoding genes.

Nature·2025

Same author

Somatostatin interneurons control the timing of developmental desynchronization in cortical networks.

Neuron·2024

Same author

Parvalbumin interneuron deficits in schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2024

Same author

Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories.

Neuron·2023

Same journal

Brain-spleen axis regulates learned fear.

Nature reviews. Neuroscience·2026

Same journal

Acetylcholine: a candidate substrate for hippocampal predictive learning?

Nature reviews. Neuroscience·2026

Same journal

Astrocytes viewed through the lens of their proteomes and subproteomes.

Nature reviews. Neuroscience·2026

Same journal

m<sup>6</sup>A in RNA: a key regulator of brain development, function and disease.

Nature reviews. Neuroscience·2026

Same journal

Non-invasive deep-brain neuromodulation by transcranial radio frequency stimulation.

Nature reviews. Neuroscience·2026

Same journal

Heading into the wild: setting the course to natural neuroscience.

Nature reviews. Neuroscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 25, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Interneuron dysfunction in psychiatric disorders.

¹Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain. o.marin@umh.es

Nature Reviews. Neuroscience

|January 19, 2012

Summary

This summary is machine-generated.

Schizophrenia, autism, and intellectual disabilities may stem from disrupted brain inhibitory circuits. Defects in interneuron development and function are implicated, offering new therapeutic targets for these neurodevelopmental disorders.

More Related Videos

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

Related Experiment Videos

Last Updated: May 25, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

Area of Science:

Neuroscience
Genetics
Developmental Biology

Background:

Schizophrenia, autism, and intellectual disabilities are complex neurodevelopmental disorders.
These conditions exhibit overlapping phenotypes and genetics, suggesting common underlying deficits.
Disruption of inhibitory circuits in the brain is increasingly recognized as a potential shared mechanism.

Purpose of the Study:

To explore the role of inhibitory circuit disruption in schizophrenia, autism, and intellectual disabilities.
To investigate the molecular basis of interneuron dysfunction in these disorders.
To identify potential therapeutic targets based on common etiological factors.

Main Methods:

Review of recent studies in animal models.
Analysis of genetic and phenotypic overlaps between disorders.
Focus on interneuron development and function.

Main Results:

Evidence suggests common deficits in inhibitory circuits across schizophrenia, autism, and intellectual disabilities.
Specific defects in interneuron development and function are linked to the molecular basis of these disruptions.
Animal models provide insights into the cellular and molecular mechanisms.

Conclusions:

Interneuron dysfunction is a unifying hypothesis for aspects of schizophrenia, autism, and intellectual disabilities.
Understanding these common deficits can improve etiological insights.
This research may pave the way for novel therapeutic strategies targeting inhibitory circuits.