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Updated: May 25, 2026
14:53
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
Published on: June 26, 2020
Stem cell therapy for cerebral ischemia: from basic science to clinical applications.
Koji Abe1, Toru Yamashita, Shunya Takizawa
1Department of Neurology, Okayama University Medical School, Okayama, Japan. abekabek@cc.okayama-u.ac.jp
Summary
Stem cell therapy shows promise for treating stroke and neurodegenerative diseases like Alzheimer's and Parkinson's. Bone marrow stem cells (BMSCs) offer neuroregenerative potential, with early trials demonstrating safety and efficacy in stroke patients.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Stem Cell Biology
Background:
- Stem cell technology offers therapeutic potential for acute ischemic stroke and neurodegenerative diseases.
- Bone marrow stem cells (BMSCs) can be mobilized for brain homing, aiding neurorepair and regeneration.
- Exogenous stem cell transplantation is progressing from basic research to clinical application.
Purpose of the Study:
- To explore the therapeutic potential of stem cell technology in neurological disorders.
- To highlight the role of bone marrow stem cells (BMSCs) in neuroregeneration.
- To review current advancements and future directions in clinical stem cell therapy for neurological conditions.
Main Methods:
- Review of current stem cell technologies and their application in neurological repair.
- Analysis of studies involving bone marrow stem cells (BMSCs) mobilization and homing.
- Examination of early clinical trial data for autologous BMSC transplantation in stroke patients.
Main Results:
- Stem cell therapy demonstrates significant neuroregenerative potential for stroke and neurodegenerative diseases.
- Mobilized bone marrow stem cells (BMSCs) show promise for neurorepair and regeneration in the brain.
- Intravenous transplantation of autologous BMSCs has shown safe and effective results in initial stroke patient trials.
Conclusions:
- Stem cell therapy holds strong therapeutic potential for acute ischemic stroke and chronic neurodegenerative diseases.
- Further research in neurovascular units, scaffold technology, and stem cell tracking will advance clinical applications.
- Stem cell therapy is poised for broader clinical integration in treating neurological conditions in the near future.
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