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Related Concept Videos

Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
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Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
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Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
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Dissociative Identity Disorder01:30

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Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
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Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
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Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
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Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Brain structure and function in borderline personality disorder.

Aisling O'Neill1, Thomas Frodl

  • 1Department of Psychiatry, Institute of Neuroscience, Trinity College, Dublin 2, Ireland.

Brain Structure & Function
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Neuroimaging studies reveal structural and functional brain differences in borderline personality disorder (BPD). Key findings include altered amygdala and hippocampus volumes and activity, alongside neurometabolic changes in BPD patients.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Borderline personality disorder (BPD) research is expanding, with increasing interest in its underlying causes and triggers.
  • Neuroimaging techniques are emerging as valuable tools for investigating BPD, though studies are still limited.

Purpose of the Study:

  • To review the current findings of neuroimaging studies in BPD.
  • To focus on structural, functional, and neurometabolic abnormalities identified in BPD patients.

Main Methods:

  • Review of existing neuroimaging literature concerning BPD.
  • Analysis of studies examining brain structure, function, and neurometabolism in BPD.

Main Results:

  • Identified reductions in the hippocampus and amygdala volumes in BPD patients compared to controls.
  • Observed exaggerated amygdala activity in BPD patients when exposed to emotional stimuli.
  • Noted correlations between amygdalar creatine levels, volume, and neurometabolic changes in the prefrontal cortex and anterior cingulate cortex.

Conclusions:

  • Neuroimaging data suggests specific structural and functional brain alterations in BPD.
  • Limitations in current studies, including sample size and methodology, are acknowledged.
  • Future neuroimaging research holds significant potential for advancing BPD understanding.