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Related Concept Videos

Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammation01:38

Inflammation

Overview
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: May 25, 2026

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo
05:44

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo

Published on: April 25, 2016

FSAP, a new player in inflammation?

F Stephan1, L A Aarden, S Zeerleder

  • 1Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.

Hamostaseologie
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Factor VII-activating protease (FSAP) is a plasma serine protease involved in coagulation and inflammation. Its precise role in hemostasis and inflammatory processes, particularly in sepsis, requires further investigation.

Related Experiment Videos

Last Updated: May 25, 2026

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo
05:44

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo

Published on: April 25, 2016

Area of Science:

  • Biochemistry
  • Hematology
  • Immunology

Background:

  • Factor VII-activating protease (FSAP) is a plasma serine protease with known roles in coagulation and fibrinolysis.
  • FSAP can activate Factor VII independently of tissue factor and cleave pro-urokinase in vitro.
  • Emerging evidence suggests FSAP involvement in inflammatory processes.

Purpose of the Study:

  • To review the structure and activation mechanisms of FSAP.
  • To discuss the potential roles of FSAP in inflammation and hemostasis.
  • To explore the implications of FSAP activation in conditions like sepsis.

Main Methods:

  • Literature review of FSAP structure, activation, and functions.
  • Analysis of in vitro studies on FSAP substrates and activity.
  • Examination of clinical data related to FSAP activation in inflammatory diseases.

Main Results:

  • FSAP modulates vascular permeability directly and indirectly via bradykinin generation.
  • FSAP is activated by apoptotic cells and removes nucleosomes during inflammation.
  • FSAP activation is observed in sepsis patients, but its net effect is unclear.

Conclusions:

  • FSAP possesses multifaceted roles beyond coagulation, extending into inflammatory pathways.
  • The precise physiological significance of FSAP activation in inflammation and hemostasis remains an open question.
  • Further research is needed to elucidate the beneficial or detrimental effects of FSAP in sepsis and other inflammatory conditions.