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Squamous cell carcinoma antigen in oral squamous cell carcinomas
1Division of Clinical Laboratory, Faculty of Dentistry, Tokyo Medical and Dental University.
The Bulletin of Tokyo Medical and Dental University
|June 1, 1990
Summary
Squamous cell carcinoma (SCC) antigen monitoring is useful for oral SCC. Elevated SCC antigen levels correlate with advanced stages and poor differentiation, aiding in tracking disease progression and treatment effectiveness.
Area of Science:
- Oncology
- Biochemistry
Background:
- Squamous cell carcinoma (SCC) antigen is a known tumor marker.
- Its utility in monitoring oral SCC requires further investigation.
Purpose of the Study:
- To evaluate the clinical usefulness of SCC antigen in managing oral squamous cell carcinomas.
- To correlate SCC antigen levels with clinicopathological features of oral SCC.
Main Methods:
- Clinicopathological and immunohistochemical analysis of 54 oral SCC cases.
- Measurement of serum SCC antigen levels.
Main Results:
- Elevated SCC antigen levels were found in 42.6% of oral SCC patients.
- Higher SCC antigen levels were associated with advanced stages and poorly differentiated tumors.
- Serum SCC antigen levels decreased post-surgery.
Conclusions:
- Serum SCC antigen is a potentially valuable biomarker for monitoring oral SCC.
- It can aid in assessing tumor extension, therapeutic response, recurrence, and metastasis.
- Immunohistochemistry showed SCC antigen in well-differentiated carcinoma cells.