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The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H)
John Mach1, Adrian W Midgley, Steve Dank
1School of Medical Science, University of New South Wales, Kensington, Australia. John.mach@unsw.edu.au
Abstract:
This study compared serum pyridine levels (NAD(+)/NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway(©)). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD(+) levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD(+) and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.
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