Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Microbes in the Production of Fermented Foods01:27

Microbes in the Production of Fermented Foods

Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Microbes in Food Production01:29

Microbes in Food Production

Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polygenic risk in early-onset coronary artery disease with low prevalence of traditional cardiovascular risk factors.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026
Same author

Enterotype-specific microbial biomarkers of immune checkpoint inhibitor response revealed by large-scale integrated metagenomic analysis.

Cancer immunology, immunotherapy : CII·2026
Same author

A genomic atlas of gut clostridia: phylogeny, butyrate, and propionate production.

Frontiers in microbiology·2026
Same author

RoMa: A Cardiopulmonary Exercise Testing Based Risk Tool in Hypertrophic Cardiomyopathy.

Journal of the American Heart Association·2026
Same author

The Role of Microbiota Metabolites Propionic Acid, p-Cresol, and 4-Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review.

Autism research : official journal of the International Society for Autism Research·2026
Same author

Non-invasive stroke volume assessment during cardiopulmonary exercise testing provides additional insight beyond O<sub>2</sub>-pulse in hypertrophic cardiomyopathy.

Scientific reports·2026

Related Experiment Video

Updated: May 25, 2026

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
08:38

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Folate production by probiotic bacteria.

Maddalena Rossi1, Alberto Amaretti, Stefano Raimondi

  • 1Department of Chemistry, University of Modena and Reggio Emilia, via Campi 183, Modena 41100, Italy. maddalena.rossi@unimore.it

Nutrients
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Certain probiotic bacteria, like Bifidobacterium and Lactobacillus, can produce folate. Studies show these folate-producing probiotics increase folate levels in rats and humans, offering a new way to prevent deficiency and its associated health risks.

Keywords:
BifidobacteriumLactobacillusfolategutmicrobiotaprobiotic

More Related Videos

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

Related Experiment Videos

Last Updated: May 25, 2026

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods
08:38

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

Area of Science:

  • Microbiology
  • Nutritional Science
  • Gastroenterology

Background:

  • Probiotic bacteria, primarily Lactobacillus and Bifidobacterium, offer health benefits including vitamin synthesis.
  • Folate (vitamin B9) is crucial for health, and its deficiency is linked to serious conditions like cancer.
  • Research focuses on identifying and utilizing probiotic strains capable of folate production for enhanced health benefits.

Purpose of the Study:

  • To investigate the folate-producing capabilities of Lactobacillus and Bifidobacterium strains.
  • To evaluate the efficacy of folate-producing probiotics in enhancing folate levels in vivo.
  • To explore the potential of these probiotics in preventing folate deficiency and associated diseases.

Main Methods:

  • Screening of Lactobacillus and Bifidobacterium strains for folate biosynthesis.
  • In vivo studies using animal models (rats) and human trials to assess folate production and absorption.
  • Analysis of folate levels in plasma, feces, and fermented products.

Main Results:

  • Lactobacillus plantarum identified as a folate-producing exception among lactobacilli, requiring para-aminobenzoic acid (pABA).
  • Several Bifidobacterium strains, particularly B. adolescentis and B. pseudocatenulatum, demonstrated significant folate production.
  • Probiotic formulations of folate-producing bifidobacteria increased plasma folate in rats and fecal folate in humans.

Conclusions:

  • Folate-producing probiotic strains represent a promising strategy for improving host folate status.
  • These probiotics can be developed into supplements or used in fermented foods to combat folate deficiency.
  • Potential applications include enhanced protection against inflammation and cancer by addressing folate deficiency-related premalignant changes.