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The negative effect of combining rhBMP-2 and Bio-Oss on bone formation for maxillary sinus augmentation
Daniel W K Kao1, Atsushi Kubota, Myron Nevins
1Department of Periodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. drdankao@gmail.com
Abstract:
Sinus augmentation with various bone graft materials may be required in the posterior maxilla. This study compared bone formation in a lateral window sinus augmentation with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ACS) combined with Bio-Oss or Bio-Oss graft alone. Patients were assigned to treatment with either rhBMP-2/ACS + Bio-Oss or Bio-Oss alone. After a healing period, bone cores were harvested. Histologic specimens demonstrated that new bone formation was less in those who received rhBMP-2/ACS + Bio-Oss than those with Bio-Oss alone. This study indicated that the addition of rhBMP-2/ACS to Bio-Oss has a negative effect on bone formation.
