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Updated: May 25, 2026

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

A 64-channel neuron recording system.

Yi-Kai Lo1, Wentai Liu, Kuanfu Chen

  • 1Electrical Engineering Department, University of California, Santa Cruz, CA 95064, USA. yikai@soe.ucsc.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
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This study introduces a low-power, integrated neuron recording system for neural signal acquisition. The system features high-density channels and efficient analog-to-digital conversion for advanced neuroscience research.

Area of Science:

  • Biomedical Engineering
  • Neuroscience Technology
  • Integrated Circuit Design

Background:

  • Advancements in neural interfaces require low-power, high-density recording systems.
  • Existing systems often face challenges with power consumption and signal fidelity.

Purpose of the Study:

  • To develop and present a fully integrated, low-power neuron recording front-end system.
  • To achieve high-density neural signal acquisition with tunable parameters and efficient digitization.

Main Methods:

  • Designed a system using TSMC 65 nm CMOS technology, incorporating two 32-channel recording modules.
  • Integrated tunable bandwidth/gain amplifiers, a multiplexer, and a 9-bit successive approximation register (SAR) analog-to-digital converter (ADC).
  • Implemented a digital control module for signal digitization, encoding, and serialization.

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A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
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Published on: May 3, 2012

A Computer-assisted Multi-electrode Patch-clamp System
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A Computer-assisted Multi-electrode Patch-clamp System

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Related Experiment Videos

Last Updated: May 25, 2026

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
09:13

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Published on: May 3, 2012

A Computer-assisted Multi-electrode Patch-clamp System
11:01

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

Main Results:

  • Achieved a low power consumption of 6 μW per channel for the recording amplifier with 3.8 μV(rms) input-referred noise.
  • The ADC digitizes neural signals at 40 kS/s with 9-bit resolution.
  • The entire system operates at 2.56 mW and occupies a compact 3 × 4 mm² area.

Conclusions:

  • The developed system offers a power-efficient and compact solution for high-density neural recording.
  • This technology holds potential for next-generation neural implants and brain-computer interfaces.
  • The tunable features and low noise performance are critical for accurate neural signal analysis.