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SN-38:β-cyclodextrin inclusion complex for in situ solidifying injectable polymer implants.

Chawan Manaspon¹, Pinunta Nittayacharn, Ketpat Vejjasilpa

¹Biomedical Engineering Department, Mahidol University, Nakorn Pathom, CO 73170, Thailand

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|January 19, 2012

Summary

This summary is machine-generated.

This study developed an injectable implant for chemotherapy drug SN-38 using a β-cyclodextrin (β-CD) complex. The optimized 1:3 SN-38:β-CD ratio achieved 89.7% encapsulation efficiency, protecting the drug.

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Area of Science:

Biomedical Engineering
Materials Science
Oncology

Background:

Chemotherapy is vital for cancer treatment but faces challenges with drug solubility and side effects.
SN-38, a potent anticancer agent, suffers from poor solubility and toxicity.
Developing effective drug delivery systems is crucial for improving cancer therapy outcomes.

Purpose of the Study:

To create an injectable, in situ forming implant for enhanced delivery of the chemotherapy drug SN-38.
To utilize a SN-38:β-cyclodextrin (β-CD) inclusion complex within a biodegradable polymer matrix.
To optimize the SN-38:β-CD ratio for improved encapsulation efficiency and controlled drug release.

Main Methods:

Formulation of an injectable polymeric implant using poly(ethylene glycol) (PEG), poly(ε-caprolactone), and poly(D, L-lactide).
Incorporation of SN-38:β-cyclodextrin (β-CD) inclusion complexes into the polymer matrix.
Evaluation of implant formation, SN-38 encapsulation efficiency, and drug release kinetics at varying SN-38:β-CD weight ratios.

Main Results:

Implant formation and SN-38 encapsulation efficiency were dependent on the SN-38:β-CD weight ratio.
A ratio of 1:7 resulted in imperfect implant formation and lower encapsulation efficiency.
A reduced ratio of 1:3 achieved a high encapsulation efficiency of 89.7%, with controlled SN-38 release.
The encapsulation process protected the active form of SN-38.

Conclusions:

An injectable SN-38:β-CD polymeric implant was successfully developed.
The SN-38:β-CD ratio significantly impacts encapsulation efficiency and drug release.
The optimized implant formulation offers a promising approach for improved chemotherapy delivery, potentially reducing side effects.