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Polymer substrate temperature sensor array for brain interfaces.

Insoo Kim1, Ho Him R Fok, Yuanyuan Li

  • 1Department of Engineering Sciences and Mechanics, The Pennsylvania State University, University Park, PA16802, USA. insoo@ psu.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
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We created an implantable thin film transistor temperature sensor (TFT-TS) for precise brain temperature monitoring. This novel sensor technology shows promise for understanding brain metabolism and neuronal activity.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Brain temperature fluctuations are linked to cerebral metabolism and neuronal activity.
  • Accurate in-vivo temperature monitoring is crucial for neuroscience research.
  • Existing methods may lack the required resolution or invasiveness for certain applications.

Purpose of the Study:

  • To develop and characterize an implantable thin film transistor temperature sensor (TFT-TS).
  • To assess the sensor's performance for measuring brain temperature changes.
  • To explore the potential of TFT-TS for monitoring cerebral metabolism and neuronal activity.

Main Methods:

  • Fabrication of two prototype TFT-TSs using high-speed ZnO TFT process on flexible polyimide substrates.

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  • Design of prototypes with diode-connected single-ended and differential-ended sensor arrays.
  • In-vitro characterization of sensor prototypes between 23-38 °C using a controlled oven and commercial sensor.

    • Main Results:

    • Successful fabrication of implantable TFT-TSs with sensor elements as small as 25 µm.
    • Demonstrated integration of TFT-TSs with external electronics via anisotropic conductive films.
    • Achieved a maximum sensitivity of 40 mV/°C from the developed TFT-TS prototypes.

    Conclusions:

    • The developed implantable TFT-TS is a viable technology for precise brain temperature measurement.
    • This sensor offers potential for advancing research into brain metabolism and neuronal activity.
    • Further in-vivo studies are warranted to validate the sensor's performance in biological systems.