Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Circuits01:25

Neural Circuits

Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neurons: The Axon01:21

Neurons: The Axon

Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.
Neuronal Communication01:28

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes.

iScience·2021
Same author

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.

Cell reports·2019
Same author

Sources of errors and uncertainties in the assessment of forest soil carbon stocks at different scales-review and recommendations.

Environmental monitoring and assessment·2016
Same author

A wearable mobility device for the blind using retina-inspired dynamic vision sensors.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2016
Same author

Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study.

PloS one·2015
Same author

A programmable analog subthreshold biomimetic model for bi-directional communication with the brain.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2013

Related Experiment Video

Updated: May 25, 2026

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Modeling neuron-glia interactions: from parametric model to neuromorphic hardware.

Viviane S Ghaderi1, Sushmita L Allam, N Ambert

  • 1Department of El University of Southern California, Los Angeles, USA. vghaderi@usc.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
Summary

Glial cells actively influence brain signal transmission. This study models neuron-glia interactions at synapses using parametric, non-parametric, and neuromorphic hardware approaches for insights into neural function.

More Related Videos

Two-Photon Polymerization 3D-Printing of Micro-scale Neuronal Cell Culture Devices
07:38

Two-Photon Polymerization 3D-Printing of Micro-scale Neuronal Cell Culture Devices

Published on: June 7, 2024

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Related Experiment Videos

Last Updated: May 25, 2026

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
10:50

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Two-Photon Polymerization 3D-Printing of Micro-scale Neuronal Cell Culture Devices
07:38

Two-Photon Polymerization 3D-Printing of Micro-scale Neuronal Cell Culture Devices

Published on: June 7, 2024

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biophysics

Background:

  • Glial cells, once considered mere support cells, are now recognized for their active role in neural signal transmission.
  • Synaptic communication involves complex interactions between neurons and glial cells, particularly astrocytes.

Purpose of the Study:

  • To investigate the mechanisms of neuron-glia interactions at synapses.
  • To model these interactions using parametric, non-parametric, and neuromorphic hardware approaches.
  • To understand the influence of astrocytic glutamate transporters on synaptic responses.

Main Methods:

  • Utilized the EONS (Elementary Objects of the Nervous System) platform for synaptic modeling.
  • Developed a parametric model of the physiological system.
  • Created a non-parametric model based on simulation results for efficient hardware implementation.
  • Employed ultra-low power subthreshold CMOS building blocks for neuromorphic hardware.

Main Results:

  • Investigated the influence of astrocytic glutamate transporters on postsynaptic responses within a tri-partite synapse micro-environment.
  • Generated simulation results capturing essential features of glutamate dynamics.
  • Successfully designed a non-parametric model suitable for efficient hardware implementation.

Conclusions:

  • The developed modeling approaches enable large-scale simulations of neuron-glial interactions.
  • These models provide valuable insights into glial modulation during normal and pathological neural function.
  • This work bridges computational modeling with hardware implementation for studying brain function.