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Related Experiment Video

Updated: May 25, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Raman based hepatocellular carcinoma biomarker detection.

M A Santiago-Cordoba1, P R Romano, A MacKay

  • 1Chemistry Department, Pennsylvania State University, University Park, PA 16802, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
Summary

Early detection of liver cancer (hepatocellular carcinoma) is improved using a novel lectin assay. This rapid and reproducible method monitors changes in a key biomarker, alpha-fetoprotein, aiding in disease diagnosis.

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Area of Science:

  • Biomedical diagnostics
  • Glycoscience
  • Nanotechnology

Background:

  • Hepatocellular carcinoma (HCC) detection requires sensitive biomarkers.
  • Alpha-fetoprotein (AFP) fucosylation correlates with HCC progression.
  • Lectins can monitor glycosylation changes in viral hepatitis (HBV, HCV).

Purpose of the Study:

  • To develop a rapid and sensitive method for analyzing lectin-based biomarkers.
  • To utilize surface-enhanced Raman spectroscopy (SERS) for detecting glycosylation changes.

Main Methods:

  • Preparation of SERS substrates with organized nanoparticles.
  • Analysis of a fucose-binding lectin, Aleuria aurantia lectin (AAL), using SERS.
  • Assessing assay speed and reproducibility.

Main Results:

  • Developed SERS substrates for lectin analysis.
  • Achieved fast (<10 seconds) detection.
  • Demonstrated high reproducibility (<5% variation).

Conclusions:

  • SERS-based lectin assay is a promising tool for HCC biomarker analysis.
  • The assay enables rapid and reproducible monitoring of glycosylation changes.
  • This technology can aid in early disease detection and patient monitoring.