Effect of self-gating on action potential firing at neuromuscular junction

The neuromuscular junction (NMJ) is the place where the axon terminal of motoneuron connects the 'endplate' of a muscle fiber. During this transduction a large depolarization (endplate potential) caused by the nerve impulse opens a large number of voltage-sensitive sodium channels at the post-junctional terminal. As a result, action potentials are generated and propagated along the muscle fiber causing contraction. This work shows simulated results of the voltage-dependent sodium channels' firing behavior at the NMJ using a mathematical model. It is found that the firing behavior of the sodium channels change basing on their activation and inactivation kinetics which are highly influenced by the self-gating behavior of the sodium conductances. The simulation results showed that self-gating of sodium channels increase conduction efficiency at the NMJ and decrease threshold for firing.