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Updated: May 25, 2026

Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells
Published on: July 18, 2019
The response of hepatocyte cell volume to hyperthermia and its role in oedema
D P O'Neill1, T Peng, S J Payne
1Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK. david.oneill@eng.ox.ac.uk
Abstract:
A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.
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