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Updated: May 25, 2026

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

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Electrical performance of penetrating microelectrodes chronically implanted in cat cortex.

Sheryl R Kane¹, Stuart F Cogan, Julia Ehrlich

¹EIC Laboratories, Inc Norwood, MA 02062, USA. skane@eiclabs.com

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|January 19, 2012

Summary

Sputtered iridium oxide (SIROF) coated electrodes show stable chronic implantation in cat cortex for over 300 days. These electrodes effectively deliver charge for neural stimulation, demonstrating potential for advanced neuroprosthetics.

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Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Chronic implantation of neural electrodes is crucial for long-term brain-computer interfaces.
Sputtered iridium oxide (SIROF) coatings offer potential for stable and effective neural electrode performance.
Understanding charge injection capabilities is vital for safe and efficient neural stimulation.

Purpose of the Study:

To evaluate the chronic performance and charge injection capacity of SIROF-coated multielectrode arrays in vivo.
To investigate the impact of stimulation parameters (pulse width, voltage biasing) on electrode function.
To characterize SIROF electrodes using electrochemical methods.

Main Methods:

Chronic implantation of SIROF-coated multielectrode arrays in cat cortex (>300 days).
In vivo measurement of voltage transients during current-controlled, cathodal stimulation.
Electrochemical characterization including open-circuit potential, cyclic voltammetry, and impedance spectroscopy.
Systematic variation of current pulse width (150-500 μs) and interpulse voltage biasing (0 V, 0.6 V vs. Ag|AgCl).

Main Results:

SIROF-coated electrodes maintained chronic implantation for over 300 days.
In vivo measurements confirmed the ability of electrodes to inject charge above neural excitation thresholds.
Stimulation parameters, including pulse width and voltage biasing, influenced electrode performance.
Electrochemical analyses provided insights into the stability and properties of the SIROF coating.

Conclusions:

SIROF-coated electrodes demonstrate long-term biocompatibility and stability for chronic neural implantation.
These electrodes possess sufficient charge injection capacity for effective neural stimulation.
The study provides valuable data for optimizing stimulation protocols using SIROF electrodes in neuroprosthetic applications.