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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
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Nerve lesioning with direct current.

E N Ravid1, L S Gan, A Prochazka

  • 1Department of Biomedical Engineering, Univerisity of Alberta, Edmonton, Alberta, Canada. ravid@ualberta.ca

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Direct Current (DC) nerve ablation offers a promising method to gradually reduce muscle over-activity. This technique shows potential for long-term attenuation of spastic hypertonus in neurological conditions.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Rehabilitation Medicine

Background:

  • Spastic hypertonus, characterized by muscle over-activity from exaggerated stretch reflexes, is a common challenge for stroke, spinal cord injury (SCI), and multiple sclerosis survivors.
  • Existing treatments for spastic hypertonus often have limitations or side effects.
  • Previous research demonstrated that Direct Current (DC) nerve lesioning can gradually attenuate muscle force for extended periods.

Purpose of the Study:

  • To investigate the feasibility of using Direct Current (DC) for controlled nerve ablation to manage spastic hypertonus.
  • To profile the specific electrical current parameters required for effective and controlled nerve ablation.

Main Methods:

  • Experimental investigation of Direct Current (DC) application for nerve lesioning.
  • Systematic profiling of electrical current levels necessary to achieve controlled nerve ablation.
  • Assessment of the gradual attenuation of muscle force following nerve ablation.

Main Results:

  • Initial experimental results demonstrate the capability of DC to induce nerve ablation.
  • The study provides data profiling the current intensity required for controlled nerve ablation.
  • The findings suggest a gradual and potentially long-lasting attenuation of muscle force.

Conclusions:

  • Direct Current (DC) nerve ablation presents a viable strategy for modulating muscle over-activity.
  • Understanding the precise current parameters is crucial for safe and effective therapeutic application.
  • This approach holds potential for managing spastic hypertonus in various neurological conditions.