A low-power high-sensitivity CMOS mixed-signal seizure-onset detector

In this paper, we present a new seizure detection algorithm and the associated CMOS circuitry implementation. The proposed low-power seizure detector is a good candidate for an implantable epilepsy prosthesis. The device is designed for patient-specific seizure detection with a one variable parameter. The parameter value is extracted from a single seizure that is subsequently excluded from the validation phase. A two-path system is also proposed to minimize the detection delay. The algorithm is first validated using MATLAB® tools and then implemented and validated using circuits designed in a standard 0.18-μm CMOS process with a total power dissipation of 7.08 μW. A total of 13 seizures from two drug-resistant epileptic patients are assessed using the proposed algorithm and resulted in 100% sensitivity and a mean detection delay of 9.7 s after electrical onset.